As the most prevalent neurodegenerative disorder, Alzheimer’s disease (AD) is characterized by memory loss and cognitive impairment clinically, the pathological hallmarks of which include amyloid-β (Aβ) and MAPT/tau (microtubule-associated protein tau) proteins that form senile plaques (SPs) and neurofibrillary tangles (NFTs) in AD brain. Bisphenol A (BPA) is an endocrine-disrupting chemical (EDC) and one of the most produced synthetic compounds worldwide, which are frequently used in food storage and baby bottles. Given BPA can interfere with various neurologic functions, Bisphenol S, one alternative of BPA, is considered a safer industrial raw material. However, researches on its biosafety are far from sufficient. In our study, we found that the neurotoxicity of BPA and BPS separately induced Tau aggregates and increased the protein level of amyloid precursor protein (APP) in AD models, which was associated with affecting the autophagy-lysosome function.