Monday, 17th November 11th International Symposium on Autophagy 2025

• Regulation of mitochondrial quality control and cellular bioenergetics during hypoxia - Anne Simonsen

Presented by:

• TM9SF3 is a Golgi-resident ATG8-binding protein essential for Golgi selective autophagy - Yixian Cui
• Mitophagic control of mitochondrial quantity in physiology and disease - Hui Jiang

• Mechanisms of selective autophagy - Sascha Martens
• Novel regulatory mechanisms of mitophagy: from transcription to post-translational modifications of PINK1 - Han-Ming SHEN
• Autophagic regulation of RNA-binding proteins - Alexandra Stolz

• Glycogen ubiquitination and its role in catabolism - Simon Cobbold
• In situ architecture of mitophagy in Drosophila development reveals ER-phagophore connectivity - Tianyu Zheng
• Spatiotemporal dynamics of physiological mitophagy in aging brain circuits - Anna Rappe
• Autophagy membrane remodelling by BAR domain containing proteins - Samuel Rodgers
• Autophagy captures the retromer-TBC1D5 complex to inhibit receptor recycling - Julian Carosi
• FOXO-regulated DEAF1 controls muscle regeneration through autophagy - Wen Xing Lee

• Cross-Species Identification of Ifc/DEGS1 as a Regulator of Lipophagy and Sphingolipid Metabolism in Rhabdomyosarcoma - Hong-Wen Tang
• Conservancy and spermiogenesis function of ribophagy receptor - Kefeng Lu
• Rab37 regulates osteopontin secretion via secretory autophagy in tumor-associated macrophages - Yi-Ching Wang
• The Drosophila Zer1 interacts with Ref(2)P to regulate autophagy and Keap1-Nrf2-mediated oxidative stress - Yi-Ting Wang
• Mechanism of bridge-type phospholipid transfer by Atg2 for autophagosome biogenesis - Yuji Sakai
• Identification of a vacuolar inhibitor of Atg15 phospholipase activity in yeast - Tomoko Horie
• In situ architecture of mitophagy in Drosophila development reveals ER-phagophore connectivity - Tianyu Zheng
• Proper ATG8-dependent recruitment of the tethering factors is important for efficient inner autophagosomal membrane degradation after lysosome fusion - Ikuko Koyama-Honda
• Interaction network that recruits the Atg2-Atg18 complex to the pre-autophagosomal structure - Yuri Yasuda
• Visualizing ATG2-mediated Fatty Acids Transport by in situ Cryo-ET -
• Deubiquitinating Enzymes USP5 and USP45 Negatively Regulate Autophagy via Distinct Mechanisms - Wen Hsin Peng
• Exploring the connection between epigenetics and autophagy: impact of 5-aza-2'-deoxycytidine treatment in cancer cells - Samir Kumar Patra
• Molecular functions and interactions of the WIPI proteins in autophagy and neurological disorders - Eleanor EA Attridge
• Deciphering the starvation induced trafficking of ATG9A in autophagosome biogenesis   - Emily Millard
• Autophagy supports resilience of neuronal quality and functions - Tomoya Eguchi
• Characterisation of PINK1-activating small molecules - Joanne L Usher
• Autophagic Protein NRBF2 Orchestrates Astrocyte Senescence and Cognitive Decline in Aging Brain - Jiahong Lu
• Determine the role of ULK1-mediated p62 phosphorylation in FUS-ALS - Jing LU
• BPA and BPS cause defective autophagy and neurodegenerative symptoms in Alzheimer’s disease models - Kejia LU
• FOXO-regulated DEAF1 controls muscle regeneration through autophagy - Wen Xing Lee
• Autophagy and Trafficking Pathways as Mediators of Immune Evasion - Umairah Abdul Khalid
• A phosphorylation-driven functional switch in p62 bodies coordinates autophagic clearance of ubiquitinated proteins - Keisuke Tabata
• Galectin-3 Directs Mitophagy in Response to Parkin-/Proteasome-Dependent Rupture of Mitochondrial Outer Membrane - Wei-Chung Chiang
• Reversible One-way Lipid Transfer at ER-Autophagosome Membrane Contact Sites via Atg2 - Li Hao
• AKAP11 controls cognitive performance by regulating TFEB-mediated autophagy - Yuxuan Kan
• STING-OPTN axis bridges mitophagy and cell fate decisions - Guang LU
• The lysosomal membrane protein LAMP2B mediates microlipophagy to target obesity-related disorders - Ryohei Sakai
• The cell autonomous and non-autonomous functions of Rab27 in longevity and neuroprotection in Drosophila - CHIH-CHIANG CHAN
• GABARAP Degradation regulated by Centriolar Satellites is Essential for DNA Damage-Induced Autophagy  - Yi-Hsuan Lin
• Mitoxantrone induces ROS-dependent elimination of dysfunctional mitochondria via mitophagy to regulate the survival of intracellular mycobacteria in dTHP-1 cells - Mousumi Das
• Caudatin from Chinese Medicine Enhances Autophagy and Lysosomal Clearance of Aβ and pTau via GSK3β/ULK1 Signaling Pathway - Ashok IYASWAMY
• Corynoxine promotes TFEB/TFE3-mediated autophagy and alleviates Aβ pathology in Alzheimer’s disease models - Xinjie GUAN
• Autophagy membrane remodelling by BAR domain containing proteins - Samuel J Rodgers
• Mitochondria in macrophages are destroyed by microautophagy - Takeshi Noda
• ANKRD13A Mediates VCP-dependent Mitochondrial Outer Membrane Rupture During PINK1/Parkin-Mediated Mitophagy - Wei-Hua Chu
• PASK negatively regulates autophagy through mTOR-independent ULK1 degradation - IN HYE LEE
• Autophagic protein NRBF2 regulates Senescent Astrocytic Deposits formation and tripartite synapse homeostasis in aging brain - erjin wang
• ESCRT-III links micronuclear instability to autophagy in cancer - APSANA LAMSAL
• Metformin vs. phenformin: targeting bulk and selective autophagy in breast cancer - Tomiris Kuandyk
• Phase separation of initiation hubs on cargo is a trigger switch for selective autophagy - Riccardo RB Babic
• Vimentin enables secretory autophagy to enhance pro-tumorigenic activity in hepatocellular carcinoma - Yan Yu Chou
• The role of Atg11 phase separation in selective autophagy - Joachim JB Brenneisen
• UBQLN and p62 Form Distinct but Interacting Ubiquitin-Positive Condensates - Hikaru Tsuchiya
• The role of unconventional autophagy in ATP-binding cassette transporters trafficking for Sorafenib resistance in Hepatocellular carcinoma - Hung-Ju Lin
• Lysosomal protein abundance and localisation alterations in neurons with TDP-43 pathology in neurodegenerative disease - Natalie Clubley

• Maintenance of lysosome membrane integrity in C. elegans - Xiaochen Wang
• Mito-Xenophagy, a pathogenic mode of autophagy in moyamoya disease - Daisuke Morito
• The crosstalk between autophagy and ubiquitin-proteasome systems in the regulation of social behavior - Congcong He

• Uncovering lysosome dependent mechanisms of cellular adaptation in cancer - Rushika Perera
• Physiological human autophagy measurement in the PBMC pool in response to nutrient restriction - Timothy J Sargeant
• Nucleophagy removes cytotoxic trapped PARP1 to prevent genomic instability: Implications for cancer therapy  - Kristijan Ramadan
• Cholesterol transfer proteins control macroautophagy-independent ER clearance - Ruoxi Wang
• Autophagy-driven lysosome recycling is essential for glycogen metabolism in skeletal muscle - Meagan McGrath