Yixian Cui
Yixian Cui
Final Degree：PhD
Professional Title：Professor
Major：Cell Biology
Research Direction：The molecular mechanism of selective autophagy and its disease relevance
Education
2003-2007 B.S. in Biology
College of Biology, Hunan University, China
2007-2013 Ph. D. in Biology, Supervisor: Dr. Bing Zhou
School of Life Sciences, Tsinghua University, China
Working Experiences
2013-2015 Postdoctoral Researcher, Supervisor: Dr. Bing Zhou
School of Life Sciences, Tsinghua University, China
2015-2019 Postdoctoral Researcher and Assistant project scientist,
Supervisor: Dr. Susan Ferro-Novick, School of Medicine, University of California San Diego, USA
2020-present Professor; Principle Investigator
Medical Research Institute, Wuhan University, China
Research Direction：Our lab is studying the molecular mechanism of selective autophagy and its disease relevance. We use yeast, fruit fly and mouse as research model organisms.
Selected Publications
[1] Yixian Cui, Smriti Parashar, Muhammad Zahoor, Patrick G. Needham, Muriel Mari, Ming Zhu, Shuliang Chen, Hsuan-Chung Ho, Fulvio Reggiori, Hesso Farhan, Jeffrey L. Brodsky, and Susan Ferro-Novick*. A COPII subunit acts with an autophagy receptor to target endoplasmic reticulum for degradation. Science 365, 53 –60, 2019;
[2] Xuehong Qian, Lingang He, Jiejie Yang, Jiajia Sun, Xueying Peng, Yuting Zhang, Yizhou Mao, Ying Zhang and Yixian Cui*. UVRAG cooperates with cargo receptors to assemble the ER-phagy site. The EMBO Journal e13625, 2023;
[3] Wenqing Mou, Yinglu Tang, Yunpeng Huang, Zhihao Wu*, Yixian Cui*. Upregulation of neuronal ER-phagy improves organismal fitness and alleviates APP toxicity. Cell Reports 43, 114255, 2024;
[4] Xuehong Qian, Jiajia Sun and Yixian Cui*. UVRAG: orchestrating the initiation of reticulophagy. Autophagy 2023;
[5] Lingang He, Xuehong Qian, Yixian Cui*. Advances in ER-phagy and its diseases relevance. Cells 10(9):2328, 2021;
[6] Yixian Cui, Smriti Parashar, and Susan Ferro-Novick*. A new role for a COPII cargo adaptor in autophagy. Autophagy Dec 3:1-3, 2019;
[7] Shuliang Chen, Yixian Cui, Smriti Parashar, Peter J. Novick*, and SusanFerro-Novick*. ER-phagy requires Lnp1, a protein that stabilizes rearrangements of the ER network. Proc Natl Acad Sci U S A 115(27), E6237-E6244, 2018;
[8] Shuliang Chen, Muriel Mari, Smriti Parashar, Dongmei Liu, Yixian Cui, Fulvio Reggiori, Peter J. Novick*, Susan Ferro-Novick*. Vps13 is required for the packaging of the ER into autophagosomes during ER-phagy. Proc Natl Acad Sci U S A 117(31), 18530-18539, 2020.