Zvulun Elazar
Zvulun (Zevi) Elazar studied for his PhD in Neuro-biochemistry at the Weizmann Institute of Science. During his postdoctoral work at Princeton and Sloan-Kettering in the lab of Jim Rothman, he studied the mechanism by which COPI vesicles are formed and their contribution to intra-Golgi transport. Since returning to the Weizmann Institute as group leader, Zevi continued to look for factors that facilitated vesicle trafficking in general and autophagy in particular. He was the first to identify, isolate, and resolve the structure of GATE-16, a member of the Atg8 protein family. In his lab, Atg4A was first characterized, and by studying the regulation of this enzyme, he discovered the complex relationship between autophagy and reactive oxygen species (ROS). His current work focuses on the mechanism of autophagosome biogenesis, particularly in regulating the autophagic isolation membrane rim by new functions of the Atg2 and Atg24 complexes.
Abstracts this author is presenting:
